Lasers Create Cancer Cure!

tumor

A substantial part of what makes cancer so deadly is that the tools we have to fight specific cancers work for some cases and don’t for others. That’s why despite numerous discoveries that promise cures for the disease, we just end up with a bunch of treatments and “therapeutic options.” Certain drugs work well against certain tumors and poorly against others. Treating cancer becomes a race to find effective treatment before the disease runs its final course.

Turns out microtubule (that I do my work on!) that help cells do things like divide and move actually might be able to extrapolate fairly accurate cancer prognoses and pathology. The proteins that make them up come in numerous forms called isotypes that differ minutely. Research indicates that different isotypes actually confer different cellular functions. For example, abundance of a particular isotype of beta-tubulin makes microtubules more dynamic and lends itself to taxane resistance in cancer cells.

Typical MALDI target

Typical MALDI target

Groundbreaking research by French researchers at Aix-Marseille Université may provide the next step in cancer treatment. Using matrix-assisted laser desorption/ionization time of flight mass spectroscopy (quite a mouthful! MALDI TOF Mass Spec for short), they found that tubulin, the protein subunit that builds microtubules, behaves unusually in the MALDI source. The result is that MALDI can detect and quantify tubulin isotypes.

E.g. isotypic distribution reading of peptide

E.g. isotypic distribution reading of peptide

Tubulin isotype analyses are expensive and time-consuming. MALDI may offer an effective screening tool for healthcare providers.

Source 1, 2, 3

Supeding

Pastry Chef (https://butterhub.org), software engineer (http://jamesding.org), and fitness enthusiast.

You may also like...

Leave a Reply

Read more:
Eat More Pizza?

  Despite the bad rep that pizza seems to have nowadays because of its relatively high caloric content (with macros...

3 Nootropics & Preventing Memory Loss [GUEST POST]

John was a high school topper. But, into his late 30’s, he had a hard time remembering things. He couldn’t...

bfsn_a_10340160_o_f0011
Organic Food & Cancer

There is a scare among consumers that contaminants in produce can increase likelihood of cancer--this drives an increasing demand for...

4097561067_16cf6986ec
New Class of Drugs to Reduce the Risk of Heart Attacks

Cardiovascular disease accounts for about 2000 deaths per day in the U.S. Costs relating to cardiovascular disease add up to...

Close